Aquaporin 3 maintains the stemness of CD133+ hepatocellular carcinoma cells by activating STAT3
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چکیده
منابع مشابه
Pim-3 Regulates Stemness of Pancreatic Cancer Cells via Activating STAT3 Signaling Pathway
Due to its aggressiveness and unusual resistance to conventional therapies, pancreatic cancer is a highly lethal gastrointestinal malignancy with poor prognosis. According to the cancer stem cell hypothesis, there exists a fraction of cancer cells, that is, cancer stem cells, responsible for tumor maintenance and therapeutic failure. Herein we investigated the involvement of proto-oncogene Pim-...
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The role of cancer stem cells (CSCs) in inducing the recurrence of hepatocellular carcinoma (HCC) after radiofrequency ablation (RFA) remains unclear. Here, we found that a dramatic increase in plasma vascular endothelial growth factor (VEGF) and an induction of local CD133+ CSCs are associated with early HCC recurrence, suggesting that VEGF expression and tumour stemness contribute to the rela...
متن کاملPrognostic Value of Combined Aquaporin 3 and Aquaporin 5 Overexpression in Hepatocellular Carcinoma
BACKGROUND Aquaporin (AQP) 3 and AQP 5 are involved in tumorigenesis and tumor progression of several tumor types. AIM To investigate expression patterns and clinical significance of AQP3 and AQP5 in hepatocellular carcinoma (HCC). METHODS Immunohistochemistry was performed to detect the expression of AQP3 and AQP5 in HCC tissues. RESULTS Immunohistochemistry analysis showed the increased...
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ژورنال
عنوان ژورنال: Cell Death & Disease
سال: 2019
ISSN: 2041-4889
DOI: 10.1038/s41419-019-1712-0